Physical Stimulations for Bone and Cartilage Regeneration

Progenitor and stem cells for bone and cartilage regeneration.

Research in regenerative medicine is developing at a significantly quick pace. Cell-based bone and cartilage replacement is an evolving therapy aiming at the treatment of patients who suffer from limb amputation, damaged tissues and various bone and cartilage-related disorders. Stem cells are undifferentiated cells with the capability to regenerate into one or more committed cell lineages. Stem...

Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface

The cartilage lesion resulting from osteoarthritis (OA) always extends into subchondral bone. It is of great importance for simultaneous regeneration of two tissues of cartilage and subchondral bone. 3D-printed Sr5(PO4)2SiO4 (SPS) bioactive ceramic scaffolds may achieve the aim of regenerating both of cartilage and subchondral bone. We hypothesized that strontium (Sr) and silicon (Si) ions rele...

Unlike bone, cartilage regeneration remains elusive.

Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlig...

Bone & Cartilage Regeneration News 01/2009

BMPs and Wnts in Bone and Cartilage Regeneration

© Springer International Publishing Switzerland 2015 H. Zreiqat et al. (eds.), A Tissue Regeneration Approach to Bone and Cartilage Repair, Mechanical Engineering Series, DOI 10.1007/978-3-319-13266-2_2 Abstract Bone morphogenetic proteins (BMPs) play an important role in osteoblast and chondrocyte differentiation and canonical Wnt signaling regulates bone mass. BMP-2 is approved for use in spi...